Linux64-bitUbuntu 14.04–18.10RHEL 6–7CentOS 6–7Debian 8–9OpenSUSE Leap 42.3, 15Fedora 28–29Mathematica 12 has been fully tested on the Linux distributions listed above. On new Linux distributions, additional compatibility libraries may need to be installed. It is likely that Mathematica will run successfully on other distributions based on the Linux kernel 2.6 or later.Mathematica supports an X Window System front end, and uses the Qt application framework for its user interface—the same used by the major Linux desktop environment KDE.
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Regular tests are run on both enterprise and popular open-source Linux distributions.